Pentobarbital will reduce the level or result of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown. pentobarbital will decrease the extent or impact of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar. Abrupt withdrawal of antiseizure drugs might enhance seizure frequency, withdraw pento... https://paulw355gzq7.wikilowdown.com/user