To gain insight into the cellular and molecular cues that promote neurovascular co-patterning at the earliest stages of human embryogenesis. we developed a human embryonic stem cell model to mimic the developing epiblast. Contact of ectoderm-derived neural cells with mesoderm-derived vasculature is initiated via the neural crest (NC). not the neural tube (NT). https://www.roneverhart.com/Castello-di-Amorosa-Il-Barone-Napa-Valley-Cabernet-Sauvignon-2007/